The Contractor Lab

Publications

Contractor Lab Publications

2024

  • Ca2+-dependent phosphodiesterase 1 regulates the plasticity of striatal spiny projection neuron glutamatergic synapses Cell Reports  [Full Paper]

Shenyu Zhai, Shintaro Otsuka, Jian Xu, Vernon R.J. Clarke, Tatiana Tkatch, David Wokosin, Zhong Xie, Asami Tanimura, Hitesh K. Agarwal, Graham C.R. Ellis-Davies, Anis Contractor, D. James Surmeier

  • The NKCC1 Inhibitor Bumetanide Restores Cortical Feedforward Inhibition and Lessens Sensory Hypersensitivity in Early Postnatal Fragile X Mice Biological Psychiatry

Nazim Kourdougli, Toshihiro Nomura, Michelle W Wu, Anouk Heuvelmans, Zoë Dobler, Anis Contractor, Carlos Portera-Cailliau

  • Notch receptor-ligand binding facilitates extracellular vesiclemediated neuron-to-neuron communication Cell Reports  [Full Paper]

Yi-Zhi Wang, Charlotte C M Castillon, Kamil K Gebis, Elizabeth T Bartom, Alessandra d’Azzo, Anis Contractor, Jeffrey N Savas

2023

  • A Pathogenic Missense Mutation in Kainate Receptors Elevates Dendritic Excitability and Synaptic Integration through Dysregulation of SK Channels The Journal of Neuroscience  [Full Paper]

Toshihiro Nomura, Sakiko Taniguchi, Yi-Zhi Wang, Nai-Hsing Yeh, Anika P Wilen, Charlotte C M Castillon, Kendall M Foote, Jian Xu, John N Armstrong, Jeffrey N Savas, Geoffrey T Swanson, Anis Contractor

  • Antipsychotic drug efficacy correlates with the modulation of D1 rather than D2 receptor-expressing striatal projection neurons Nature Neuroscience  [Full Paper]

Seongsik Yun , Ben Yang, Justin D. Anair, Madison M. Martin, Stefan W. Fleps, Arin Pamukcu, Nai-Hsing Yeh, Anis Contractor, Ann Kennedy & Jones G. Parker

Press:  Wired Magazine – “Everyone Was Wrong About Antipsychotics”

2022

  • Intersectional mapping of multi-transmitter neurons and other cell types in the brain Cell Reports  [Full Paper]

Jian Xu, Andrew Jo, Raina P DeVries, Sercan Deniz, Suraj Cherian, Idris Sunmola, Xingqi Song, John J Marshall, Katherine A Gruner, Tanya L Daigle, Anis Contractor, Talia N Lerner, Hongkui Zeng, Yongling Zhu

2021

  • Kainate receptors regulate the functional properties of young adult-born dentate granule cells.  Cell Reports  [Full Paper]

Zhu, Y., Armstrong, J.A., Contractor, A.

  • Cortical interneurons in autism.  Nature Neuroscience  [Full Paper]

Contractor, A., Ethell, I.M., Portera-Cailliau, C.

  • Genetic disruption of Grm5 causes complex alterations in motor activity, anxiety and social behaviors.  Behavioural Brain Research  [Full Paper]

Xu J., Marshall J.J., Kraniotis S., Nomura T., Zhu, Y., Contractor, A.

  • Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer’s Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals.  Cell Systems  [Full Paper]

Hark T.J., Rao N.R., Castillon C., Basta T., Smukowski S., Bao H., Upadhyay A., Bomba-Warczak E., Nomura T., O’Toole E.T., Morgan G.P., Ali L., Saito T., Guillermier C., Saido T.C., Steinhauser M.L., Stowell M.H.B.,  Chapman E.R., Contractor A., Savas J.N.

2020

  • Recruitment of parvalbumin and somatostatin interneuron inputs to adult born dentate granule neurons.  Scientific Reports  [Full Paper]

Remmers, C.L., Castillion, C.C.M., Armstrong, J.N., Contractor, A.

  • Neuronal BIN1 regulates presynaptic neurotransmitter release and memory consolidation.  Cell Reports  [Full Paper]

De Rossi, P., Nomura, T., Andrew, R.J., Masse, N., Sampathkumar, V., Musial, T., Sudwarts, A. Recupero A.J., Le Metayer, T., Hansen, M., Shim, H.N., Krause, S., Freedman, D.J., Bindokas, V., Kasthuri, N., Nicholson, D.A., Contractor, A., Thinakaran, G.

2019

  • Activating newborn neurons suppresses depression and anxiety-like behaviors. Nat Comms [Full Paper] 

Tunc-Ozan, E., Peng, C-Y., Zhu, Y., Dunlop, S., Contractor, A., Kessler, J.A

  • Potentiating α2 subunit containing perisomatic GABAA receptors protects against seizures in a mouse model of Dravet syndrome.  The Journal of Physiology  [Full Paper]

Nomura T, Hawkins NA, Kearney JA, George AL Jr, Contractor A.